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Biomarkers and Aging in the News


Laser pointers should be thrown away, say safety experts
Parents are being warned that their children's eyesight could be at risk.
11 Dec 2018 at 9:35am

Increased breast cancer risk might last decades after childbirth, study says
Compared with women who have never had children, women who have given birth may have an increased breast cancer risk that continues for up to 23 years after their most recent birth, according to a new study published in the journal Annals of Internal Medicine on Monday.
10 Dec 2018 at 5:00pm


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Phys Ed: Is Aerobic Exercise the Key to Successful Aging?
Aerobic activities like jogging and interval training can make our cells biologically younger; weight training did not have the same effect.
12 Dec 2018 at 5:00am

Is Screen Time Bad for Kids? Brains?
A study featured on ?60 Minutes? is sure to alarm parents. Here?s what scientists know, and don?t know, about the link between screens, behavior, and development.
10 Dec 2018 at 3:16pm


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Phys Ed: Is Aerobic Exercise the Key to Successful Aging?
Aerobic activities like jogging and interval training can make our cells biologically younger; weight training did not have the same effect.
12 Dec 2018 at 5:00am

Is Screen Time Bad for Kids? Brains?
A study featured on ?60 Minutes? is sure to alarm parents. Here?s what scientists know, and don?t know, about the link between screens, behavior, and development.
10 Dec 2018 at 3:16pm

Observation of the geometric phase effect in the H + HD -> H2 + D reaction

Theory has established the importance of geometric phase (GP) effects in the adiabatic dynamics of molecular systems with a conical intersection connecting the ground- and excited-state potential energy surfaces, but direct observation of their manifestation in chemical reactions remains a major challenge. Here, we report a high-resolution crossed molecular beams study of the H + HD -> H2 + D reaction at a collision energy slightly above the conical intersection. Velocity map ion imaging reve...


13 Dec 2018 at 1:38pm

1.9-million- and 2.4-million-year-old artifacts and stone tool-cutmarked bone...

East Africa has provided the earliest known evidence for Oldowan stone artifacts and hominin-induced stone tool cutmarks dated to ~2.6 million years (Ma) ago. The ~1.8-million-year-old stone artifacts from Ain Hanech (Algeria) were considered to represent the oldest archaeological materials in North Africa. Here we report older stone artifacts and cutmarked bones excavated from two nearby deposits at Ain Boucherit estimated to ~1.9 Ma ago, and the older to ~2.4 Ma ago. Hence, the Ain Boucherit e...


13 Dec 2018 at 1:38pm

Neuron-specific signatures in the chromosomal connectome associated with schi...

To explore the developmental reorganization of the three-dimensional genome of the brain in the context of neuropsychiatric disease, we monitored chromosomal conformations in differentiating neural progenitor cells. Neuronal and glial differentiation was associated with widespread developmental remodeling of the chromosomal contact map and included interactions anchored in common variant sequences that confer heritable risk for schizophrenia. We describe cell type–specific chromosomal conn...


13 Dec 2018 at 1:38pm

Genome-wide de novo risk score implicates promoter variation in autism spectr...

Whole-genome sequencing (WGS) has facilitated the first genome-wide evaluations of the contribution of de novo noncoding mutations to complex disorders. Using WGS, we identified 255,106 de novo mutations among sample genomes from members of 1902 quartet families in which one child, but not a sibling or their parents, was affected by autism spectrum disorder (ASD). In contrast to coding mutations, no noncoding functional annotation category, analyzed in isolation, was significantly associated wit...


13 Dec 2018 at 1:38pm

Integrative functional genomic analysis of human brain development and neurop...

To broaden our understanding of human neurodevelopment, we profiled transcriptomic and epigenomic landscapes across brain regions and/or cell types for the entire span of prenatal and postnatal development. Integrative analysis revealed temporal, regional, sex, and cell type–specific dynamics. We observed a global transcriptomic cup-shaped pattern, characterized by a late fetal transition associated with sharply decreased regional differences and changes in cellular composition and maturat...


13 Dec 2018 at 1:38pm

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bip...

Most genetic risk for psychiatric disease lies in regulatory regions, implicating pathogenic dysregulation of gene expression and splicing. However, comprehensive assessments of transcriptomic organization in diseased brains are limited. In this work, we integrated genotypes and RNA sequencing in brain samples from 1695 individuals with autism spectrum disorder (ASD), schizophrenia, and bipolar disorder, as well as controls. More than 25% of the transcriptome exhibits differential splicing or ex...


13 Dec 2018 at 1:38pm

Comprehensive functional genomic resource and integrative model for the human...

Despite progress in defining genetic risk for psychiatric disorders, their molecular mechanisms remain elusive. Addressing this, the PsychENCODE Consortium has generated a comprehensive online resource for the adult brain across 1866 individuals. The PsychENCODE resource contains ~79,000 brain-active enhancers, sets of Hi-C linkages, and topologically associating domains; single-cell expression profiles for many cell types; expression quantitative-trait loci (QTLs); and further QTLs associated w...


13 Dec 2018 at 1:38pm

Hospital Discharge Around Holidays Can Be Riskier
People discharged from the hospital during the Christmas break period had a higher risk of death or readmission compared with people discharged at other times, new research shows.
10 Dec 2018 at 7:15pm

Autism, ADHD Tied to Raised Risk in Siblings
Younger siblings of children with autism have a 30-fold increased relative risk they'll be diagnosed with autism themselves. They're also nearly four times as likely to be diagnosed with ADHD, researchers report.
10 Dec 2018 at 3:15pm

Have Heart Failure? Flu Shot May Save Your Life
People who were recently diagnosed with heart failure and got a flu shot cut their risk of premature death by 18 percent, compared with not getting a shot, according to a new study from Denmark.
10 Dec 2018 at 1:15pm

Electronic Health Records Bogging Docs Down
Managing electronic health records is creating ?technology-related stress? for physicians, and primary care doctors are most at risk, according to a new survey.
10 Dec 2018 at 1:15pm

Opioids Exact Another Toll on Newborns: Smaller Heads
Infants born addicted to opioids had significantly smaller head circumferences, researchers have found, potentially putting them at higher risk for mental health and developmental problems.
10 Dec 2018 at 9:15am


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