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Proceedings of the National Academy of Sciences

[Anthropology] Male dominance rarely skews the frequency distribution of Y ch...

A central tenet of evolutionary social science holds that behaviors, such as those associated with social dominance, produce fitness effects...



[Anthropology] Paleoindian demography and the extraterrestrial impact hypothesis

Recently it has been suggested that one or more large extraterrestrial (ET) objects struck northern North America 12,900 ± 100...



[Psychology] The spontaneous expression of pride and shame: Evidence for biol...

The present research examined whether the recognizable nonverbal expressions associated with pride and shame may be biologically innate behavioral responses...



[Evolution] Ancient, recurrent phage attacks and recombination shaped dynamic...

Mobile genetic elements have impacted biological evolution across all studied organisms, but evidence for a role in evolutionary emergence of...



[Genetics] Abrogation of T cell quiescence characterizes patients at high ris...

Clinically isolated syndrome (CIS) refers to the earliest clinical manifestation of multiple sclerosis (MS). Currently there are no prognostic biological...



[Genetics] Accumulation of mutants in "aging" bacterial colonies is due to gr...

Several bacterial systems show behavior interpreted as evidence for stress-induced mutagenesis (adaptive mutation), a postulated process by which nongrowing cells...



[Immunology] The CD83 reporter mouse elucidates the activity of the CD83 prom...

CD83 is the major surface marker identifying mature dendritic cells (DCs). In this study, we report the generation of reporter...



[Immunology] Acquired hematopoietic stem cell defects determine B-cell repert...

Aging is associated with an inability to mount protective antibody responses to vaccines and infectious agents. This decline is associated...



[Neuroscience] Dynamic changes in accumbens dopamine correlate with learning ...

Dopamine in the nucleus accumbens (NAc) is an important neurotransmitter for reward-seeking behaviors such as intracranial self-stimulation (ICSS), although its...



[Neuroscience] Successful choice behavior is associated with distinct and coh...

Successful decision making requires an ability to monitor contexts, actions, and outcomes. The anterior cingulate cortex (ACC) is thought to...



[Neuroscience] Hierarchical coding for sequential task events in the monkey p...

The frontal lobes play a key role in sequential organization of behavior. Little is known, however, of the way frontal...



[Neuroscience] Enhanced contextual fear memory in central serotonin-deficient...

Central serotonin (5-HT) dysregulation contributes to the susceptibility for mental disorders, including depression, anxiety, and posttraumatic stress disorder, and learning...



[Physiology] UCP2 is highly expressed in pancreatic {alpha}-cells and influen...

In pancreatic β-cells, uncoupling protein 2 (UCP2) influences mitochondrial oxidative phosphorylation and insulin secretion. Here, we show that -cells express...



[Psychology-BS] Bayesian motion estimation accounts for a surprising bias in ...

Determining the approach of a moving object is a vital survival skill that depends on the brain combining information about...



[Perspective] Colloquium Paper: In the light of evolution II: Biodiversity an...

[Colloquium] Colloquium Paper: Ecological extinction and evolution in the bra...

The great mass extinctions of the fossil record were a major creative force that provided entirely new kinds of opportunities...



[Cell_Biology] AIMP2/p38, the scaffold for the multi-tRNA synthetase complex,...

AIMP2/p38 is a scaffolding protein required for the assembly of the macromolecular tRNA synthetase complex. Here, we describe a previously...



[Immunology] CXCR4 antagonism increases T cell trafficking in the central ner...

The migration of lymphocytes into the CNS during viral encephalitis is hindered by the blood–brain barrier (BBB) such that most...



[Immunology] Diverse cytokine production by NKT cell subsets and identificati...

NKT cell subsets can be divided based on CD4 and NK1.1 expression and tissue of origin, but the developmental and...



[Medical_Sciences] Proteins induced by telomere dysfunction and DNA damage re...

Telomere dysfunction limits the proliferative capacity of human cells by activation of DNA damage responses, inducing senescence or apoptosis. In...



[Neuroscience] Electroconvulsive seizure and VEGF increase the proliferation ...

All classes of antidepressants increase hippocampal cell proliferation and neurogenesis, which contributes, in part, to the behavioral actions of these...



[Neuroscience] From the Cover: Loss of PINK1 causes mitochondrial functional ...

Parkinson's disease (PD) is a common neurodegenerative disorder thought to be associated with mitochondrial dysfunction. Loss of function mutations in...



[Physiology] Shear-induced reorganization of renal proximal tubule cell actin...

In this study, we demonstrate that fluid shear stress (FSS)-induced actin cytoskeletal reorganization and junctional formation in renal epithelial cells...