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Proceedings of the National Academy of Sciences
• Evolution, design, and genomic suboptimality: Does science "save theology"? [...• Rapid evolution of ritual architecture in central Polynesia indicated by prec...
In Polynesia, the complex Society Islands chiefdoms constructed elaborate temples (marae), some of which reached monumental proportions and were associated...
• From the Cover: Regulation of cell motile behavior by crosstalk between cadhe...
During normal development and in disease, cohesive tissues undergo rearrangements that require integration of signals from cell adhesions to neighboring...
• Metacaspase Yca1 is required for clearance of insoluble protein aggregates [C...
In complex organisms, caspase proteases mediate a variety of cell behaviors, including proliferation, differentiation, and programmed cell death/apoptosis. Structural homologs...
• Origin of a function by tandem gene duplication limits the evolutionary capab...
The most remarkable outcome of a gene duplication event is the evolution of a novel function. Little information exists on...
• Surprising gene expression patterns within and between PDF-containing circadi...
To compare circadian gene expression within highly discrete neuronal populations, we separately purified and characterized two adjacent but distinct groups...
• Learning-dependent plasticity with and without training in the human brain [N...
Long-term experience through development and evolution and shorter-term training in adulthood have both been suggested to contribute to the optimization...
• Bacteria with a eukaryotic touch: A glimpse of ancient evolution? [Commentaries]
• Irrelevant events affect voters' evaluations of government performance [Polit...
Does information irrelevant to government performance affect voting behavior? If so, how does this help us understand the mechanisms underlying...
• Adverse interactions between micro-RNAs and target genes from different speci...
It is commonly assumed but not proven that microRNAs (miRNAs) and their targets coevolve. Under this assumption, miRNAs and targets...
• A conserved pattern of brain scaling from sharks to primates [Evolution]
Several patterns of brain allometry previously observed in mammals have been found to hold for sharks and related taxa (chondrichthyans)...
• Limits to gene flow in a cosmopolitan marine planktonic diatom [Evolution]
The role of geographic isolation in marine microbial speciation is hotly debated because of the high dispersal potential and large...
• Patriline shifting leads to apparent genetic caste determination in harvester...
The harvester ant, Pogonomyrmex occidentalis, is characterized by high levels of intracolonial genetic diversity resulting from multiple mating by the...
• Identification of a pheromone regulating caste differentiation in termites [E...
The hallmark of social insects is their caste system: reproduction is primarily monopolized by queens, whereas workers specialize in the...
• A time-invariant principle of genome evolution [Genetics]
Uncovering general principles of genome evolution that are time-invariant and that operate in germ and somatic cells has implications for...
• c-Ret-mediated hearing loss in mice with Hirschsprung disease [Medical_Sciences]
A significantly increased risk for dominant sensorineural deafness in patients who have Hirschsprung disease (HSCR) caused by endothelin receptor type...
• Extranuclear estrogen receptor-{alpha} stimulates NeuroD1 binding to the insu...
Estrogen receptors (ERs) protect pancreatic islet survival in mice through rapid extranuclear actions. ER also enhances insulin synthesis in cultured...
• Correlated memory defects and hippocampal dendritic spine loss after acute st...
Stress affects the hippocampus, a brain region crucial for memory. In rodents, acute stress may reduce density of dendritic spines,...
• Similar patterns of cortical expansion during human development and evolution...
The cerebral cortex of the human infant at term is complexly folded in a similar fashion to adult cortex but...
• Neurofibromin regulates corticostriatal inhibitory networks during working me...
Neurofibromatosis type I (NF1) is one of the most common single-gene causes of learning disabilities. Here, we use behavioral working...
• Prion protein interaction with stress-inducible protein 1 enhances neuronal p...
Transmissible spongiform encephalopathies are fatal neurodegenerative diseases caused by the conversion of prion protein (PrPC) into an infectious isoform (PrPSc)....
• Individual histories and selection in heterogeneous populations [Evolution]
The strength of selection in populations has traditionally been inferred by measuring changes in bulk population parameters, such as mean...
• Differential changes in steroid hormones before competition in bonobos and ch...
A large body of research has demonstrated that variation in competitive behavior across species and individuals is linked to variation...
• Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in grow...
mTOR-generated signals play critical roles in growth of leukemic cells by controlling mRNA translation of genes that promote mitogenic responses....
• Bcl-XL represents a druggable molecular vulnerability during aurora B inhibit...
Aurora kinase B inhibitors induce apoptosis secondary to polyploidization and have entered clinical trials as an emerging class of neocytotoxic...
• Laminar and columnar auditory cortex in avian brain [Neuroscience]
The mammalian neocortex mediates complex cognitive behaviors, such as sensory perception, decision making, and language. The evolutionary history of the...
• A single social defeat reduces aggression in a highly aggressive strain of Dr...
Genes and prior experience both influence the behavior of animals, but the relative contribution of each to fighting behavior in...
• Ultrahigh-resolution microstructural diffusion tensor imaging reveals perfora...
The perforant path (PP) undergoes synaptic changes in the course of aging and dementia. Previous studies attempting to assess the...